Stiftelsen lantbruksforskning

Lantbruks- och trädgårdsföretagarnas egen forskningsstiftelse finansierar behovsdriven forskning för svenska förhållanden.
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Sykdomskontroll og forbedret dyrevelferd ved hjelp av genetiske markører: En pilotstudie av osteochondrose og Birkelandfraktur hos hest

Status: Avslutat
Projektnummer: H1247154
Kategori: Research program | Horse
Ansökningsår: 2012
Datum för slutrapport: 30 september 2018
Huvudsökande: Gunnar Klemetsdal
Organisation: Universitetet for miljø og biovitenskap (UMB)
E-postadress: Gunnar.Klemetsdal@umb.no
Telefon: ?
Medsökande: Nils Ivar Dolvik
Medsökande: Sigrid Lykkjen

The project aims to verify our current findings of QTLs with effect on osteochondrosis and Birkelandfracture in the Standarbred trotter. The project triples the sizes of the groups in the genome-wise association studies. The project will serve a basis for international involvement, either to identidy QTLs or in genomic selection.

Prosjektets mål er å verifiserer våre nåværende funn av QTLer med effect på osteochondrose og Birkelandfraktur hos varmblodstraver. Prosjektet tredobler størrelsen på forsøksgruppene i de genom-vide assosiasjonsstudiene. Prosjektet vil også være et springbrett for å komme inn i internasjonalt sammarbeid, enten for å finne QTLer, eller i genomisk seleksjon.

Ett mål i prosjektet var å verifisere QTL funnene som tidligere er rapportert av Lykkjen og medarbeidere på osteokondrose og Birkelandfraktur på varmblodstraver. Ved å øke materialet betydelig falt mange QTL bort, og bare en QTL på kromosom 28 var signifikant. En vil nå søke å tilnærme det mulige underliggende genet ved å utnytte kandidatgener. Med bare ett signifikant QTL funn, bør fremtidig forskning på OCD og POF ikke bare rettes inn mot å utnytte noe av genetisk varians ved å fokusere en QTL tilnærming, men heller ved å utnytte en mye større andel av genetisk variasjon gjennom genetisk seleksjon. Hos hest bør dette gjennomføres over populasjon av travere, men også inkludere data på varmblods ridehest. Relevante data vil i store trekk finnes i forskjellige forskningsprosjekt. Et slikt over-populasjons initiativ på OCD kan sees på som en modell for andre sykdommer, og andre arter, som heller ikke har etablert sykdomsregistering.

Osteochondrosis dissecans (OCD) and Birkelandfracture, are diseases mainly in the hock and fetlock joints of varmblooded horses, respectively, that increase the costs in the horse industry and affect animal welfare negatively, since many horses have to be operated. The diseases contribute to increased costs for treatment and restitution, reduced performance and income as well as reduced value of the animal itself. High frequencies of the diseases illustrate the importance of revealing the causative nature of OCD and POF.

Selection can be used as a preventive means towards such diseases, either on the quantitative trait loci (QTL) itself or on estimated breeding values, by summing the effect of all alleles into a genomic breeding value. The project aimed at verifying QTL findings that have been reported by Lykkjen and coworkers for OCD and POF in the Standardbred trotter. By considerably increasing the size of the material of Lykkjen and coworkers, only the finding of a QTL on chromosome 28 still held promise as a QTL. Our approach now is to use the candidate gene approach to possibly reveal the underlying causative gene. With only one QTL left to consider, this indicates that future research towards improving the genetics of OCD and POF should be approached by not only utilizing some of the genetic variance through a QTL approach, but rather to utilize more of the genetic variance through genomic selection, across populations of trotter, but also including data from riding horse populations. Such data will in main be available through research projects. Such an across-population initiative on OCD can be considered a model for other diseases, as well, and even for other species that do not either have a disease recording system in place.

In the same material, we also estimated the effect of inbreeding on racing performance. The effect was negative, i.e. that racing performance in Standardbred trotters is concluded depressed by inbreeding In corollary, crossbreeding is encouraged, and is one explanation of the recently increased contribution of French trotter in the Norwegian population of Standardbreds.

 

Antal träffar i projektbanken: 1647

Karaktärisering av hjärtkärlfunktionen hos insulinresistenta hästar
Katarina Nostell, SLU

Projektnummer: H-14-47-020 • Status: Avslutat • Datum för slutrapport: 29 juni 2018

Insulin resistance and obesity are common in humans and horses. There is a strong correlation between insulin resistance and laminitis in horses but the pathogenesis of laminitis is not known. One hypothesis is that the development of laminitis is related to an insulin induced dysfunction of the …

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Forbedret behandling for økt overlevelse etter leddinfeksjon hos føll
Kristin Olstad, Norges miljø- og biovitenskapelige universitet

Projektnummer: H-14-47-051 • Status: Avslutat • Datum för slutrapport: 29 juni 2018

Bacterial infection in joints, or septic arthritis, is an important problem in foals because it leads to non-weight bearing lameness that affects the foal’s welfare and because survival after treatment can be as low as 42 %. The prognosis for coming to start in a race is also reduced. A study …

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Hästens och människans välfärd och värdighet
Henrik Lerner, Ersta Sköndal högskola

Projektnummer: H-16-47-177 • Status: Avslutat • Datum för slutrapport: 29 juni 2018

The aim of our project is to develop an ethical evaluation tool for Equine Assisted Therapy that considers the welfare and the dignity of both horse and human. This tool will facilitate the evaluation of a practice giving information on the good life of both the horse and the human. If the practice …

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Inverkan av såtidpunkt och utsädesmängd på avkastningen hos aktuella typsorter av höstvete
Jannie Hagman, Sveriges lantbruksuniversitet, SLU

Projektnummer: H1333056 • Status: Avslutat • Datum för slutrapport: 21 juni 2018

Winter wheat harvests shows large variations over the years, and for the optimal plant population in the spring sowing time, stand establishment and winter survival is crucial. We want to examine the relation between sowing time, seed rate and temperature, and how it affects winter wheat crop …

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Gräsbaserad effektiv nötkreatursproduktion - effekter på ekosystemtjänster och ekonomi
Christel Cederberg

Projektnummer: O-15-21-571 • Status: Avslutat • Datum för slutrapport: 12 juni 2018

Kött
Mjölk

A large share of agricultural land is used for cattle production. This land use is important for ecosystem
services and biodiversity. Abandonment of grazed pastureland is a reality. Consumer interest is growing
for environmentally friendly produced milk and beef with high animal welfare standards; …

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Bete morgon och kväll eller på natten, viket fungerar bäst på gårdar med automatisk mjölkning?
Eva Spörndly, Sveriges Lantbruksuniversitet - SLU

Projektnummer: V1430016 • Status: Avslutat • Datum för slutrapport: 25 maj 2018

Part time grazing where dairy cows are offered high pasture allowance during daytime has given good results compared with exercise pasture. We now want to study if even better results can be achieved with part-time grazing morning+evening or at night. Results have shown that automatically milked …

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Påverkas hästars återhämtning efter arbete av uppstallningsformen?
Anna Jansson, Sveriges Lantbruksuniversitet

Projektnummer: H-16-47-194 • Status: Avslutat • Datum för slutrapport: 15 maj 2018

The aim of the proposed project is to examine whether recovery after competition in horses is affected by housing system. Our hypothesis is that horses kept in a housing system where they can move freely in groups recover faster than horses kept in box stalls. We performed such a study in 2015 and, …

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Övervakning av Drosophila suzukii och riskbedömning för svensk bärodling
Teun Dekker, Sveriges Lantbruksuniversitet

Projektnummer: S-15-56-589 • Status: Avslutat • Datum för slutrapport: 6 april 2018

The invasive fruit fly Drosophila suzukii is spreading in Sweden, from detection of only a few individuals in 2014, to damage in raspberry in 2015. Considering its multibillion € footprint in the EU and US, we urgently need to analyze the crops at risk, and establish measures to minimize spread and …

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MALDI-TOF snabb test av bakterier i let-vätske från hästar med misstänkt let-infektion.
Pia Haubro Andersen, Sveriges lantbruksuniversitet, SLU

Projektnummer: H1247133 • Status: Avslutat • Datum för slutrapport: 28 februari 2018

Many horses with bacterial infection of a synovial structure do not survive or regain their full athletic performance. One essential prognostic factor is time from contamination until correct treatment is initiated. Proper treatment requires a microbiological diagnosis and this process takes 2 -3 …

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Interaktiv jordartskarta
Kristin Piikki

Projektnummer: O-15-20-566 • Status: Avslutat • Datum för slutrapport: 27 februari 2018

Växtodling

In 2015, SLU in collaboration with SGU will complete the new Farm Soil Map of Sweden (FSMS), a detailed map of topsoil texture of arable land in Sweden. This new, publicly available, information will lower the threshold to start precision farming and help targeting the implementation of …

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