According to applicable legislation, manure and digestate must be sanitized in order to prevent disease transmission before they may be merchandised on the open market. Swedish plants currently have the choice between using one of two standard methods (70 °C for 1 h, or 52 °C for 10 h), or carry out an expensive validation of the process in order to use other parameters. By preparing for the establishment of further nationally approved standard hygienisation methods, this project will contribute to a better profitability in the handling of manure and digestate. Based on a screening of other countries’ rules, interviews, a literature survey and lab scale experiments, we will propose at least 5 new methods which will comply with the legislative requirements for hygienisation. Since the affected authority, the Swedish Board of Agriculture, is part of the reference group, it is likely that the proposed methods will get implemented in the approval of future plants.