Acquired equine polyneuropathy (AEP) is a devastating neurologic disease affecting Nordic horses. Characteristic histopathological changes have been shown in the peripheral nerves of horses euthanized due to the disease. These include re- and demyelination as well as hypertrophy of perikaria and proteinaceous inclusions in the myelinproducing Schwann cells. The hypothesis is that an unknown factor, possibly from forage, disrupts the Schwann cell metabolism. Further studies is needed in order to elucidate the aetiology, but the availability of nervesamples is limited as they need to be sampled in immediate association with euthanasia. Transport to pathology units is mostly not feasible due to the severity of clinical signs, making collected samples very valuable. To overcome this challenge we intend to establish Schwann cell cultures, allowing freezing and thawing for further studies. The method is already established at NMBU for dogs and will be applied in affected and control horses.