Stiftelsen lantbruksforskning

Lantbruks- och trädgårdsföretagarnas egen forskningsstiftelse finansierar behovsdriven forskning för svenska förhållanden.
Läs mer

Forståelse av etiologien bak acquired equine polyneuropathy via studier av Schwanske celle kulturer

Status: Pågående
Projektnummer: H-18-47-409
Kategori: Research program | Horse
Ansökningsår: 2018
Datum för slutrapport: 30 juni 2023
Huvudsökande: siv Hanche-Olsen
Organisation: NMBU Veterinærhøgskolen
E-postadress: siv.hanche-olsen@nmbu.no
Telefon: +4767232388
Medsökande: Gjermund Gunnes
Medsökande: Gittan Gröndahl
Beviljade medel: 240 000 SEK

Acquired equine polyneuropathy (AEP) is a devastating neurologic disease affecting Nordic horses. Characteristic histopathological changes have been shown in the peripheral nerves of horses euthanized due to the disease. These include re- and demyelination as well as hypertrophy of perikaria and proteinaceous inclusions in the myelinproducing Schwann cells. The hypothesis is that an unknown factor, possibly from forage, disrupts the Schwann cell metabolism. Further studies is needed in order to elucidate the aetiology, but the availability of nervesamples is limited as they need to be sampled in immediate association with euthanasia. Transport to pathology units is mostly not feasible due to the severity of clinical signs, making collected samples very valuable. To overcome this challenge we intend to establish Schwann cell cultures, allowing freezing and thawing for further studies. The method is already established at NMBU for dogs and will be applied in affected and control horses.

Acquired equine polyneuropathy (AEP) er en dramatisk nervesykdom som rammer nordiske hester. Det er påvist karakteristiske histopatologiske forandringer i de perifere nervene på hester avlivet pga sykdommen. Disse inkluderer re- og demyelinisering, samt hypertrofi av perikaria og proteinlignende inklusjoner i de myelinproduserende Schwanske cellene. Hypotesen er at en ukjent faktor, muligens fra fôret, påvirker metabolismen i de Schwanske cellene og fremkaller forandringene. Det er nødvendig med videre studier for å kunne belyse årsaksforholdene, men begrenset tilgang på prøver har vanskeliggjort dette. Prøvene må tas ut i umiddelbar tilknytning til avlivning og mange AEP affiserte hester kan ikke transporteres til patologi-enheter. Prøver som tas ut er dermed svært verdifulle. Ved å dyrke Schwanske celler i kulturer vil dette problemet omgås fordi man kan fryse og tine dem opp igjen til videre undersøkelser. Metoden er alt etablert på NMBU for hund og vil benyttes i studien på hest.

 

Antal träffar i projektbanken: 1712

Förbättring av klimat i fjäderfästall - för bättre djurhälsa, produktion och mindre miljöpåverkan
Helene Oscarsson, Vreta Kluster AB

Projektnummer: R-20-62-328 • Status: Pågående • Ansökningsår: 2020

Achieving and maintaining a good stable climate with low ammonia levels is a major challenge for many poultry farmers. In addition to adversely affecting animal health, production and the working environment, high levels of ammonia in the stable can also lead to increased environmental impact. The …

Läs mer

Hur stor del av mjölkkornas dräktighetsförluster kan förklaras av olika genetiska defekter?
Britt Berglund

Projektnummer: O-19-20-305 • Status: Pågående • Ansökningsår: 2019

Milk

The project aims are to use the information about cow's DNA profile to estimate the severity of fertility problems caused by specific genetic defects in the Swedish Red (SRB) and Holstein dairy breeds, and to estimate the economic impact of pregnancy losses caused by these genetic defects. Our goal …

Läs mer

Utveckling av Bästa praxis inom svensk klövvård
Evgenij Telezhenko

Projektnummer: O-19-20-318 • Status: Pågående • Ansökningsår: 2019

Meat
Milk

Every year, about 500,000 claw trimmings are recorded in Swedish dairy cattle. The aim of claw trimming is to detect, treat and prevent painful claw lesions. However, the claw trimming in itself can be harmful and cause claw lesions if it is not done correctly. The aim of the project is to develop …

Läs mer

Att förbereda för framtiden: uthålliga odlingssystem utan glyfosat
Alexander Menegat

Projektnummer: O-19-20-299 • Status: Pågående • Ansökningsår: 2019

Crop production

We work with the vision that it possible to reduce herbicide use and completely abandon glyphosate in reduced and no-till systems by promoting soil health and crop vigour through a diverse crop rotation, cover crops and mechanical weed control. In field experiments, we compare innovative glyphosate …

Läs mer

Beslutsstöd och integrerade bekämpningsstrategier för rapsskadegörarna skidgallmygga och blygrå rapsvivel
Peter Anderson

Projektnummer: O-19-20-320 • Status: Pågående • Ansökningsår: 2019

Crop production

The Brassica pod midge Dasineura brassicae and its facilitator, the cabbage seed pod weevil Ceutorrhynchus obstrictus, have caused serious damage in oilseed rape crops during the last few years. No locally adapted IPM strategies exist, including pesticide management thresholds with evidentiary …

Läs mer

Innovativ salixförädling för fossilfritt drivmedel
Pär Ingvarsson

Projektnummer: O-19-22-292 • Status: Pågående • Ansökningsår: 2019

Energy and biomass

The conversion into a bio-based economy in Sweden requires a broad range of initiatives. One of the challenges is that additional sources of biomass will be needed. High yield potential, low conversion and production costs are critical success factors for new raw material. Salix is an energy crop …

Läs mer

SamZoner 2.0 - Optimering av multifunktionella skyddszoner för ökad biologisk bekämpning och pollinering
Maria Viketoft

Projektnummer: O-19-23-298 • Status: Pågående • Ansökningsår: 2019

Crop production
Horticulture

Adding flowers to the cropping system that support beneficial insects is a promising option to achieve crop protection
in Swedish agriculture and horticulture. However, the wide-spread adoption of this approach has been hampered by
limited economic benefit and the risk of propagating pests and …

Läs mer

Objektiv måling av øvre luftvegs obstruksjon i Norsk og Svenske travhester
Eric Strand, NMBU, Norway

Projektnummer: H-19-47-472 • Status: Pågående • Ansökningsår: 2019

Upper respiratory tract (URT) collapse during exercise is one of the most common causes of poor performance in
sporting horses worldwide. Evaluation of laryngeal/ pharyngeal collapse during exercise in horses is currently graded
subjectively from videoendoscopic recordings on a treadmill or from …

Läs mer

Diagnos av parasitsjukdomar hos hästar med hjälp av mikrofluidik och mobiltelefonbaserad mikroskopi
Jonas Tegenfeldt, Lunds Universitet

Projektnummer: H-19-47-493 • Status: Pågående • Ansökningsår: 2019

All horses grazing freely are at risk of parasitic diseases. Due to a growing problem with drug resistance in parasites, there is a need to improve the diagnostic methods. One important problem with today's situation is that one diagnostic procedure costs significantly more than one treatment, both …

Läs mer

Brukningsmetoder för ökad markkvalité och högre skördestabilitet under extremväder
Thomas Keller

Projektnummer: O-19-23-309 • Status: Pågående • Ansökningsår: 2019

Crop production

Climate projections for Sweden indicate higher temperatures during summer and larger variability in precipitation between years. This poses enormous challenges for Swedish agriculture. The main aim of this project is to investigate relationships between soil management, soil quality and crop yield. …

Läs mer
Prenumerera på vårt nyhetsbrev