Stiftelsen lantbruksforskning

Lantbruks- och trädgårdsföretagarnas egen forskningsstiftelse finansierar behovsdriven forskning för svenska förhållanden.
Läs mer

Forståelse av etiologien bak acquired equine polyneuropathy via studier av Schwanske celle kulturer

Status: Pågående
Projektnummer: H-18-47-409
Kategori: Research program | Horse
Ansökningsår: 2018
Datum för slutrapport: 30 juni 2023
Huvudsökande: siv Hanche-Olsen
Organisation: NMBU Veterinærhøgskolen
E-postadress: siv.hanche-olsen@nmbu.no
Telefon: +4767232388
Medsökande: Gjermund Gunnes
Medsökande: Gittan Gröndahl
Beviljade medel: 240 000 SEK

Acquired equine polyneuropathy (AEP) is a devastating neurologic disease affecting Nordic horses. Characteristic histopathological changes have been shown in the peripheral nerves of horses euthanized due to the disease. These include re- and demyelination as well as hypertrophy of perikaria and proteinaceous inclusions in the myelinproducing Schwann cells. The hypothesis is that an unknown factor, possibly from forage, disrupts the Schwann cell metabolism. Further studies is needed in order to elucidate the aetiology, but the availability of nervesamples is limited as they need to be sampled in immediate association with euthanasia. Transport to pathology units is mostly not feasible due to the severity of clinical signs, making collected samples very valuable. To overcome this challenge we intend to establish Schwann cell cultures, allowing freezing and thawing for further studies. The method is already established at NMBU for dogs and will be applied in affected and control horses.

Acquired equine polyneuropathy (AEP) er en dramatisk nervesykdom som rammer nordiske hester. Det er påvist karakteristiske histopatologiske forandringer i de perifere nervene på hester avlivet pga sykdommen. Disse inkluderer re- og demyelinisering, samt hypertrofi av perikaria og proteinlignende inklusjoner i de myelinproduserende Schwanske cellene. Hypotesen er at en ukjent faktor, muligens fra fôret, påvirker metabolismen i de Schwanske cellene og fremkaller forandringene. Det er nødvendig med videre studier for å kunne belyse årsaksforholdene, men begrenset tilgang på prøver har vanskeliggjort dette. Prøvene må tas ut i umiddelbar tilknytning til avlivning og mange AEP affiserte hester kan ikke transporteres til patologi-enheter. Prøver som tas ut er dermed svært verdifulle. Ved å dyrke Schwanske celler i kulturer vil dette problemet omgås fordi man kan fryse og tine dem opp igjen til videre undersøkelser. Metoden er alt etablert på NMBU for hund og vil benyttes i studien på hest.

 

Antal träffar i projektbanken: 1722

Är de för små för att rida? En studie av ridskolornas aktiviteter för förskolebarn från säkerhets- och hästvälfärdsperspektiv
Susanna Hedenborg, Malmö University

Projektnummer: H-18-47-383 • Status: Pågående • Ansökningsår: 2018

A few years ago, media reported on a 7 year-old girl who was killed during a riding lesson. The accident evokes questions about children, horses and safety. Children are small and horses big, and the horse is a herd and prey animal whose behaviour is partly controlled by instincts. Today, many …

Läs mer

Finns 'Hopparknä' hos häst?- en studie av patellardesmopati som orsak till knähälta hos sporthästar
Marie Rhodin, Sveriges Lantbruksuniversitet

Projektnummer: H-18-47-393 • Status: Pågående • Ansökningsår: 2018

Soft tissues around the kneecap (patella) as a cause of equine lameness is an area yet to be scientifically investigated but that is often clinically treated with “alternative” methods without an established diagnosis. In human medicine, patellar tendinosis is a common verified diagnosis. …

Läs mer

Forståelse av etiologien bak acquired equine polyneuropathy via studier av Schwanske celle kulturer
siv Hanche-Olsen, NMBU Veterinærhøgskolen

Projektnummer: H-18-47-409 • Status: Pågående • Ansökningsår: 2018

Acquired equine polyneuropathy (AEP) is a devastating neurologic disease affecting Nordic horses. Characteristic histopathological changes have been shown in the peripheral nerves of horses euthanized due to the disease. These include re- and demyelination as well as hypertrophy of perikaria and …

Läs mer

Nya hortikulturella substrat från den fasta fraktionen av biogas produktion
Håkan Asp, Sveriges lantbruks universitet

Projektnummer: R-18-25-143 • Status: Pågående • Ansökningsår: 2018

Green house production depends or reliable substrates and fertilizers. Peat is the dominating substrate in Sweden and internationally. There is a debate about reducing the peat use since the mining for peat may increase climate gas emissions and disturb sensitive ecosystems. Thus, alternative for …

Läs mer

Kolfastläggningspotential i matjorden och alven - analys av markdatabaser och långliggande försök
Thomas Kätterer

Projektnummer: O-18-23-141 • Status: Pågående • Ansökningsår: 2018

Energi & biomassa
Kött
Mjölk
Växtodling

Humus is an important indicator of soil quality and soil organic carbon (SOC) sequestration is a cost-effective measure to reduce the climatic impact of food production systems. The national soil-monitoring program (SMP) show an upward trend in SOC during the past 20 years, mostly attributed to an …

Läs mer

Fältförutsättningar för lyckad löklagring med minskat svinn
Lars Mogren, SLU

Projektnummer: R-18-25-146 • Status: Pågående • Ansökningsår: 2018

Consumers appreciate onions in all kinds of cooking. Onions can be grown in Sweden with good results. Onions can be stored for a long period. There is a potential to increase the self-sufficiency in onions. To achieve this, a better knowledge of long-term-storage potential indicator factors that …

Läs mer

Mjölkfettsyror - verktyg för att hitta kor med ökad risk för ämnesomsättningssjukdomar och reproduktionsstörningar
Kjell Holtenius

Projektnummer: O-19-20-306 • Status: Pågående • Ansökningsår: 2019

Milk

The overall objective of this project is to create milk biomarkers based on specific milk fatty acids for identification of cows with reproductive disorders and metabolic disturbances. Milk will be analysed by Fourier-transform mid-infrared technology. An important value of this project for the …

Läs mer

Marmorerad, mör och miljövänlig - jakten på det perfekta nötköttet
Mats Emilson, Agroväst Livsmedel AB

Projektnummer: R-20-62-327 • Status: Pågående • Ansökningsår: 2020

More and more consumers desire a tasty meat where production have considered the environmental impact and animal welfare. The purpose of this interdisciplinary project is to determine how to produce such a product while still make the production profitable, climate efficient and otherwise …

Läs mer

Mer vall på slätten för klimateffektiv produktion
Håkan Schroeder, SLU

Projektnummer: R-20-62-324 • Status: Pågående • Ansökningsår: 2020

Agriculture in plain-lands is often specialized in crop production, with no on-farm use of ley as animal fodder, and crop rotations that often includes only annual crops (e.g. oilseed rape, cereals and sugar beets). At the same time, integrating ley in arable cropping systems generates several …

Läs mer

Cannabinoider – Säkert foder, ren sport och framtida potential till häst
Matilda Lampinen Salomonsson, SVA

Projektnummer: H-19-47-486 • Status: Pågående • Ansökningsår: 2019

Cannabinoids have potential to induce analgesia and muscle relaxation which would be beneficial for equine practice. Today there is no drug labelled for veterinary use containing these cannabinoids, but there are some herbal oil products which unofficially have been reported to be used in horses, …

Läs mer
Prenumerera på vårt nyhetsbrev