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Forståelse av etiologien bak acquired equine polyneuropathy via studier av Schwanske celle kulturer

Status: Pågående
Projektnummer: H-18-47-409
Kategori: Research program | Horse
Ansökningsår: 2018
Datum för slutrapport: 30 juni 2022
Huvudsökande: siv Hanche-Olsen
Organisation: NMBU Veterinærhøgskolen
E-postadress: siv.hanche-olsen@nmbu.no
Telefon: +4767232388
Medsökande: Gjermund Gunnes
Medsökande: Gittan Gröndahl
Beviljade medel: 240 000 SEK

Acquired equine polyneuropathy (AEP) is a devastating neurologic disease affecting Nordic horses. Characteristic histopathological changes have been shown in the peripheral nerves of horses euthanized due to the disease. These include re- and demyelination as well as hypertrophy of perikaria and proteinaceous inclusions in the myelinproducing Schwann cells. The hypothesis is that an unknown factor, possibly from forage, disrupts the Schwann cell metabolism. Further studies is needed in order to elucidate the aetiology, but the availability of nervesamples is limited as they need to be sampled in immediate association with euthanasia. Transport to pathology units is mostly not feasible due to the severity of clinical signs, making collected samples very valuable. To overcome this challenge we intend to establish Schwann cell cultures, allowing freezing and thawing for further studies. The method is already established at NMBU for dogs and will be applied in affected and control horses.

Acquired equine polyneuropathy (AEP) er en dramatisk nervesykdom som rammer nordiske hester. Det er påvist karakteristiske histopatologiske forandringer i de perifere nervene på hester avlivet pga sykdommen. Disse inkluderer re- og demyelinisering, samt hypertrofi av perikaria og proteinlignende inklusjoner i de myelinproduserende Schwanske cellene. Hypotesen er at en ukjent faktor, muligens fra fôret, påvirker metabolismen i de Schwanske cellene og fremkaller forandringene. Det er nødvendig med videre studier for å kunne belyse årsaksforholdene, men begrenset tilgang på prøver har vanskeliggjort dette. Prøvene må tas ut i umiddelbar tilknytning til avlivning og mange AEP affiserte hester kan ikke transporteres til patologi-enheter. Prøver som tas ut er dermed svært verdifulle. Ved å dyrke Schwanske celler i kulturer vil dette problemet omgås fordi man kan fryse og tine dem opp igjen til videre undersøkelser. Metoden er alt etablert på NMBU for hund og vil benyttes i studien på hest.

 

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