Lantbruks- och trädgårdsföretagarnas egen forskningsstiftelse finansierar behovsdriven forskning för svenska förhållanden.
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Lantbruks- och trädgårdsföretagarnas egen forskningsstiftelse finansierar behovsdriven forskning för svenska förhållanden.
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Status: | Pågående |
Projektnummer: | H-18-47-406 |
Kategori: | Research program | Horse |
Ansökningsår: | 2018 |
Huvudsökande: | Sofia Mikko |
Organisation: | Sveriges lantbruksuniversitet |
E-postadress: | Sofia.Mikko@slu.se |
Telefon: | +46-18-671979 |
Medsökande: | Tomas Bergström |
Medsökande: | null null |
The overall aim of this project is to improve equine health and welfare by identifying causative mutations for inherited diseases to aid informed breeding of healthy horses. We will use a comparative genomics approach, combining whole-genome sequencing (WGS) and bioinformatics with state-of-the-art clinical diagnosis of disease phenotypes. In the project a general framework for mutation-detection of equine monogenetic diseases will be developed. The initial focus will be on anophthalmia and microphthalmia, potentially autosomal recessive disease/s, recently observed among Swedish Warmblood horses. The objectives of the study are to:
1. clinically define monogenic diseases with autosomal recessive inheritance,
2. develop a general framework for identifying disease causing mutation with a bioinformatics pipeline for whole-genome sequencing,
3. develop a plan for breeding advise in different scenarios of inheritance patterns, and severity of the disease.
Det övergripande målet med detta projekt är att förbättra hästens hälsa och välfärd genom att identifiera orsaken till ärftliga sjukdomar och att stödja en kunskapsbaserad uppfödning av friska hästar. Vi kommer att kombinera helgenomsekvenser (WGS) och bioinformatik med kliniska diagnoser av sjukdomsfenotypen. I projektet kommer en generell “pipeline” för mutationsdetektering av monogena sjukdomar hos häst att utvecklas. Initial kommer fokus att ligga på anoftalmi och mikroftalmi, potentiellt autosomal recessiv sjukdomar, som nyligen observerats bland svenska varmblodshästar (SWB). Syftet med studien är att:
1. kliniskt definiera monogena sjukdomar med autosomalt recessivt arv,
2. utveckla en “pipeline” för att identifiera sjukdomsframkallande mutationer med bioinformatik och helgenomsekvensering,
3. Utveckla en plan för avelsrådgivning i olika scenarier av arvsmönster och svårighetsgrad av sjukdom.
Projektnummer: O-20-20-456 • Status: Pågående • Ansökningsår: 2020
Spread of barnyard grass, growing in southern Sweden has accelerated during the last decade and is rapidly moving northwards. No herbicide-resistant populations have been reported from Sweden thus far, but it is only a matter of time before barnyard grass will develop herbicide resistance in …
Läs merProjektnummer: O-20-20-472 • Status: Pågående • Ansökningsår: 2020
Cereal production is limited by many different factors. Leaf diseases are often well known, while diseases on roots are more difficult to identify. Root diseases are often caused by oomycetes, fungus-like microorganisms that live for years in soil and on old root debris, parasitizing the roots of …
Läs merProjektnummer: O-20-20-453 • Status: Pågående • Ansökningsår: 2020
A sustainable use of phosphorus fertilizers has engaged a large number of researchers, especially how to measure
the soil content of available phosphorus. However, the development of results to useful methods for agriculture has
not been a priority. The recommendations are based on extraction with …
Projektnummer: O-21-23-624 • Status: Pågående • Ansökningsår: 2021
It is well known that storage of animal manure and digestate causes emissions of methane (CH4), nitrous oxide (N2O) and ammonia (NH3). A crust on liquid manure acts both as a physical barrier for NH3 and as a biofilter that oxidize CH4 and NH3. However, N2O can be formed in some crusts, and there …
Läs merProjektnummer: H-21-47-653 • Status: Pågående • Ansökningsår: 2021
The aim of the project is to characterize genomic diversity and inbreeding, within and between Nordic native horse breeds, with special focus on the Norwegian and Swedish breeds. For this we will use whole genome sequencing of individual and pooled DNA samples. Genomic characterization is an …
Läs merProjektnummer: H-21-47-641 • Status: Pågående • Ansökningsår: 2021
Insulin dysregulation and hyperinsulinemia is a horse welfare problem that also increase the incidence of the severely painful condition laminitis in horses. Today, no pharmacological treatment is available but recent weak evidence suggest that Sodium-glucose cotransporters (SGLT) inhibitors (e.g. …
Läs merProjektnummer: O-21-20-623 • Status: Pågående • Ansökningsår: 2021
The bacterium Lawsonia intracellularis causes the disease proliferative enteropathy. The bacterium is present in >40% of the Swedish piglet-producing herds and production losses are estimated to 2 900 SEK per sow and year. The disease is spread by faeces and the pigs are usually affected after …
Läs merProjektnummer: H-21-47-649 • Status: Pågående • Ansökningsår: 2021
It is generally accepted that muscle enzyme activity (CK and AST) levels in plasma may increase in Standardbreds and Thoroughbreds after exercise and racing, indicating muscle damage. However, in one recent study on healthy Standardbred trotters fed a forage only diet muscle enzyme activity levels …
Läs merProjektnummer: O-21-23-622 • Status: Pågående • Ansökningsår: 2021
Structure liming on clayey soils (>15% clay) is one of the prioritized measures for mitigation of phosphorous losses to surrounding water. This project increases the knowledge about the effect of structure liming on phosphorous leaching losses on short and long term by investigating the timing and …
Läs merProjektnummer: H-21-47-636 • Status: Pågående • Ansökningsår: 2021
An alarmingly high number of accidents involve humans and horses and the welfare of many horses is compromised as shown by signs of discomfort specifically during ridden work. Research indicates that this is due to miscommunication between riders/handlers and horses and mismanagement caused by …
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