Lantbruks- och trädgårdsföretagarnas egen forskningsstiftelse finansierar behovsdriven forskning för svenska förhållanden.
Läs mer
Lantbruks- och trädgårdsföretagarnas egen forskningsstiftelse finansierar behovsdriven forskning för svenska förhållanden.
Läs mer
Status: | Pågående |
Projektnummer: | H-18-47-406 |
Kategori: | Research program | Horse |
Ansökningsår: | 2018 |
Huvudsökande: | Sofia Mikko |
Organisation: | Sveriges lantbruksuniversitet |
E-postadress: | Sofia.Mikko@slu.se |
Telefon: | +46-18-671979 |
Medsökande: | Tomas Bergström |
Medsökande: | null null |
The overall aim of this project is to improve equine health and welfare by identifying causative mutations for inherited diseases to aid informed breeding of healthy horses. We will use a comparative genomics approach, combining whole-genome sequencing (WGS) and bioinformatics with state-of-the-art clinical diagnosis of disease phenotypes. In the project a general framework for mutation-detection of equine monogenetic diseases will be developed. The initial focus will be on anophthalmia and microphthalmia, potentially autosomal recessive disease/s, recently observed among Swedish Warmblood horses. The objectives of the study are to:
1. clinically define monogenic diseases with autosomal recessive inheritance,
2. develop a general framework for identifying disease causing mutation with a bioinformatics pipeline for whole-genome sequencing,
3. develop a plan for breeding advise in different scenarios of inheritance patterns, and severity of the disease.
Det övergripande målet med detta projekt är att förbättra hästens hälsa och välfärd genom att identifiera orsaken till ärftliga sjukdomar och att stödja en kunskapsbaserad uppfödning av friska hästar. Vi kommer att kombinera helgenomsekvenser (WGS) och bioinformatik med kliniska diagnoser av sjukdomsfenotypen. I projektet kommer en generell “pipeline” för mutationsdetektering av monogena sjukdomar hos häst att utvecklas. Initial kommer fokus att ligga på anoftalmi och mikroftalmi, potentiellt autosomal recessiv sjukdomar, som nyligen observerats bland svenska varmblodshästar (SWB). Syftet med studien är att:
1. kliniskt definiera monogena sjukdomar med autosomalt recessivt arv,
2. utveckla en “pipeline” för att identifiera sjukdomsframkallande mutationer med bioinformatik och helgenomsekvensering,
3. Utveckla en plan för avelsrådgivning i olika scenarier av arvsmönster och svårighetsgrad av sjukdom.
Projektnummer: R-18-25-147 • Status: Pågående • Ansökningsår: 2018
Strawberry is an important horticultural crop with an annual production of 566 MSEK. A higher competitiveness of the Swedish strawberry industry is paramount in order to sustain and develop it for the future. To secure high yields of good quality, superior cultivars and optimal management are …
Läs merProjektnummer: O-18-20-175 • Status: Pågående • Ansökningsår: 2018
The project aims to lay the foundation for genomic selection in Swedish beef cattle populations. Genomic selection has revolutionized animal breeding and much increased genetic progress in e.g. dairy cattle. Improved animal breeding increases production efficiency and genomic selection enables …
Läs merProjektnummer: H-18-47-406 • Status: Pågående • Ansökningsår: 2018
The overall aim of this project is to improve equine health and welfare by identifying causative mutations for inherited diseases to aid informed breeding of healthy horses. We will use a comparative genomics approach, combining whole-genome sequencing (WGS) and bioinformatics with state-of-the-art …
Läs merProjektnummer: H-17-47-287 • Status: Pågående • Ansökningsår: 2017
Grass for grazing or forage production contains variable amounts of carbohydrates, which often are described as the good (fiber), the bad (sugar) and the ugly (fructans) in relation to prevention, and development of diseases like insulin resistance and laminitis. There is a large variation in …
Läs merProjektnummer: H-18-47-393 • Status: Pågående • Ansökningsår: 2018
Soft tissues around the kneecap (patella) as a cause of equine lameness is an area yet to be scientifically investigated but that is often clinically treated with “alternative” methods without an established diagnosis. In human medicine, patellar tendinosis is a common verified diagnosis. …
Läs merProjektnummer: H-18-47-401 • Status: Pågående • Ansökningsår: 2018
The goal of the applied project is to shed light on overlooked aspects of the complex subject of horse welfare.
Because of the specific position stall owners have, they are especially suitable to contribute to our knowledge about
the possibilities and limitations that set the conditions for …
Projektnummer: R-18-26-136 • Status: Pågående • Ansökningsår: 2018
Sustainable dairy systems must strive for practices that reduce the negative impacts and enhance the positive impacts, and find measures to track changes in relation to different goals. The aim of this project is to investigate how indicators and tools for ecosystem services and biodiversity can be …
Läs merProjektnummer: O-18-20-162 • Status: Pågående • Ansökningsår: 2018
The goal is models for translating satellite data from the time of supplementary fertilisation directly to nitrogen (N) recommendation maps. The crops are winter wheat (Triticum aestivum L.) and malting barley (Hordeum vulgare L.). A new multispectral camera for drones, with nine bands of the same …
Läs merProjektnummer: R-18-25-146 • Status: Pågående • Ansökningsår: 2018
Consumers appreciate onions in all kinds of cooking. Onions can be grown in Sweden with good results. Onions can be stored for a long period. There is a potential to increase the self-sufficiency in onions. To achieve this, a better knowledge of long-term-storage potential indicator factors that …
Läs merProjektnummer: 0230044 • Status: Avslutat • Datum för slutrapport: