Lantbruks- och trädgårdsföretagarnas egen forskningsstiftelse finansierar behovsdriven forskning för svenska förhållanden.
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Lantbruks- och trädgårdsföretagarnas egen forskningsstiftelse finansierar behovsdriven forskning för svenska förhållanden.
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Status: | Pågående |
Projektnummer: | H-20-47-568 |
Kategori: | Research program | Horse |
Ansökningsår: | 2020 |
Huvudsökande: | Caroline Fossum |
Organisation: | SLU |
E-postadress: | Caroline.Fossum@slu.se |
Telefon: | 018-672782 |
Medsökande: | Stina Hellman |
Medsökande: | null null |
The proposed project aims to continue research for development of a vaccine protective against the pathogenic equine parasite Strongylus vulgaris. The ongoing work to establish appropriate in vitro models to screen the effect of candidate vaccine antigens/adjuvants will be continued. Cytokine screenings in cultures of equine PBMC and intestinal organoids will enable studies of both the systemic (PBMC) and local (organoids) response to parasite antigens. Our main antigen candidate, the recombinant protein SvSXP, will be evaluated together with a novel adjuvant, G3, first in our in vitro systems and thereafter in an immunisation trial in collaboration with experts on parasite immunology at the University of Kentucky. In search of additional vaccine antigens a bacteriophage cDNA library constructed from migrating S. vulgaris larvae will be utilized. Bacteriophage clones expressing promising larval antigens will be further propagated and tested for inclusion in the vaccine formula.
Projektet syftar till att fortsätta utvecklingen av ett vaccin som skyddar mot hästens farligaste inälvsparasiter, Strongylus vulgaris. Det redan påbörjade projektet med att etablera in vitro modeller för att screena immunreaktioner mot olika kandidatantigen/adjuvans planeras fortsätta. Genom att mäta cytokinsvaret i cellkulturer bestående av mononukleära blodceller och tarmorganoider kan både de systemiska (blodceller) och lokala (organoider) immunreaktionerna mot olika parasitantigen utvärderas. Kandidatantigenet SvSXP kommer tillsammans med ett nytt adjuvans, G3, att utvärderas först in vitro och sedan i ett vaccinationsförsök i samarbete med erfarna parasitimmunologer vid University of Kentucky. För att finna ytterligare vaccinantigen kommer ett redan existerande S.vulgaris cDNA bibliotek att användas. Kloner som visar potential att inkluderas i vaccinformuleringen kommer att testas och utvärderas med den etablerade metodologin.
Projektnummer: R-21-25-509 • Status: Pågående • Ansökningsår: 2021
Fruit tree canker, caused by the fungus Neonectria ditissima, has become a threat for Swedish apple production. No efficient protective measures are available and no complete genetic resistance is known in apple. However, apple genotypes differ in the level of partial resistance which must be fully …
Läs merProjektnummer: O-21-20-615 • Status: Pågående • Ansökningsår: 2021
Healthy seeds are a prerequisite for sustainable food systems. The seed-borne plant disease, common bunt (CB) in wheat, caused by the fungi Tilletia tritici and T. laevis, is a major problem in agriculture. Efficient chemical seed treatments exist, but it is often difficult to keep up with autumn …
Läs merProjektnummer: O-21-20-635 • Status: Pågående • Ansökningsår: 2021
Dairy cows are an important part of a sustainable and resilient food production as they facilitate circular flows on the farm and contribute to carbon sequestration, open landscapes and biodiversity. To achieve a sustainable dairy production in all parts of Sweden, we need large as well as small …
Läs merProjektnummer: O-21-20-619 • Status: Pågående • Ansökningsår: 2021
Colibacillosis is a common disease in poultry and includes both local and systemic infections. Increased knowledge is necessary for development of effective methods to prevent disease, such as improved management routines, modification of environment, and vaccine development. The first study (WP1) …
Läs merProjektnummer: JTI-21-83-609 • Status: Pågående • Ansökningsår: 2021
A major challenge facing agriculture is handling water excess and deficit exacerbated by climate change, while reducing eutrophication. Controlled drainage (CD) has the potential to address these issues and improve yield stability. Despite CDs clear benefits and state subsidies for CD installation, …
Läs merProjektnummer: O-18-20-158 • Status: Pågående • Ansökningsår: 2018
The purpose of this project is to identify the transmission routes for Campylobacter to broiler flocks and recommend actions at farm level to reduce the number of chickens with Campylobacter. Furthermore, to analyse routines at slaughter including cleaning of slaughterhouses and transport crates to …
Läs merProjektnummer: R-18-25-147 • Status: Pågående • Ansökningsår: 2018
Strawberry is an important horticultural crop with an annual production of 566 MSEK. A higher competitiveness of the Swedish strawberry industry is paramount in order to sustain and develop it for the future. To secure high yields of good quality, superior cultivars and optimal management are …
Läs merProjektnummer: O-18-20-165 • Status: Pågående • Ansökningsår: 2018
Insufficient crop protection is an increasingly limiting factor for crop production. Damage by slugs and cabbage stem flea beetles in winter oilseed rape are timely examples of increasing crop protection problems in Sweden. We will test whether companion cropping winter oilseed rape with frost …
Läs merProjektnummer: O-18-20-175 • Status: Pågående • Ansökningsår: 2018
The project aims to lay the foundation for genomic selection in Swedish beef cattle populations. Genomic selection has revolutionized animal breeding and much increased genetic progress in e.g. dairy cattle. Improved animal breeding increases production efficiency and genomic selection enables …
Läs merProjektnummer: O-17-23-959 • Status: Pågående • Ansökningsår: 2017
Soil compaction is a threat to soil ecosystem services and negatively affects crop productivity, causing huge costs to farmers and society. The main aim of the project is to raise awareness of soil compaction. We will i) refine the freely accessible soil compaction decision support tool …
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