Lantbruks- och trädgårdsföretagarnas egen forskningsstiftelse finansierar behovsdriven forskning för svenska förhållanden.
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Lantbruks- och trädgårdsföretagarnas egen forskningsstiftelse finansierar behovsdriven forskning för svenska förhållanden.
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Status: | Pågående |
Projektnummer: | H-18-47-390 |
Kategori: | Research program | Horse |
Ansökningsår: | 2018 |
Huvudsökande: | Johan Bröjer |
Organisation: | SLU |
E-postadress: | johan.brojer@slu.se |
Telefon: | 018-671388 |
Medsökande: | Sanna Truelsen Lindåse |
Medsökande: | null null |
Laminitis, an extremely painful disease of the equine foot, is most commonly caused by elevated insulin
concentrations in blood (hyperinsulinemia). Therefore, strategies to reduce hyperinsulinemia in horses are warranted.
Studies in obese children with insulin dysregulation and hyperinsulinemia have identified elevated levels of the
hormone glucagon in blood. To identify novel treatment strategies for preventing laminitis we compared insulin
dysregulation in the horse with that observed in humans. We found that horses with insulin dysregulation also had an
excessive glucagon secretion during an oral sugar test in a small pilot study.
If the results of the pilot study hold true also for a larger population of horses, this would be a breakthrough in the
understanding of the pathophysiology of insulin dysregulation in the horse. This opens up for medical treatment of
these horses since there are treatment strategies for an abnormal glucagon response in humans with -cell
dysregulation.
Fång, en smärtsam sjukdom som drabbas hästens hov, orsakas i de flesta fall av förhöjda koncentrationer av insulin i
blodet (hyperinsulinemi). På grund av detta samband finns det ett stort behov av att finna metoder, som minskar
graden av hyperinsulinemi hos häst.Studier utförda på överviktiga barn med störd insulinmetabolism och hyperinsulinemi har funnit förhöjda nivåer av hormonet glukagon i blodet. I likhet med dessa resultat har vår forskargrupp i en mindre pilotstudie visat att hästar med hyperinsulinemi också hade en ökad frisättning av glukagon under ett oralt glukostoleranstest.
Om vi studerar detta samband i en större hästpopulation och då påvisar samma resultat som i pilotstudien, skulle det
innebära ett stor genombrott i förståelsen om hur hyperinsulinemi uppstår hos häst. Det skulle innebära att nya
behandlingsmetoder mot hyperinsulinemi hos häst blir tillgängliga, då det redan finns behandlingsstrategier med
läkemedel vid störd glukagonmetabolism hos människa.
Projektnummer: O-19-20-319 • Status: Pågående • Ansökningsår: 2019
This project aims to modify existing sensor systems for adapted nitrogen fertilization to consider water stress at
supplementary fertilization in cereals. Different approaches to consider sensor data and soil information will be tested
in field trials. Current commercial systems interpret water …
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Automation technology is developing rapidly, not least in agriculture. Several of the biggest challenges in vehicular automation technology, such as complex interactions with other road users, are less problematic for agricultural vehicles than for road vehicles. There is therefore potential for …
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Worm infections in free-range layers are increasingly causing health problem in the poultry industry. Despite this, there are knowledge gaps about how worms are detected in living laying hens and on methods for how they can be controlled in modern free-range housing systems. The objectives of the …
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About 200 dairy farms in Sweden use recycled manure solids (RMS) as bedding material and the number is increasing. Advantages is low price, reliable availability and good cow comfort. The main disadvantage is the risk of increased bacterial growth on the lying area affecting especially udder health …
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The project aims are to use the information about cow's DNA profile to estimate the severity of fertility problems caused by specific genetic defects in the Swedish Red (SRB) and Holstein dairy breeds, and to estimate the economic impact of pregnancy losses caused by these genetic defects. Our goal …
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Every year, about 500,000 claw trimmings are recorded in Swedish dairy cattle. The aim of claw trimming is to detect, treat and prevent painful claw lesions. However, the claw trimming in itself can be harmful and cause claw lesions if it is not done correctly. The aim of the project is to develop …
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