Stiftelsen lantbruksforskning

Lantbruks- och trädgårdsföretagarnas egen forskningsstiftelse finansierar behovsdriven forskning för svenska förhållanden.
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Sykdomskontroll og forbedret dyrevelferd ved hjelp av genetiske markører: En pilotstudie av osteochondrose og Birkelandfraktur hos hest

Status: Avslutat
Projektnummer: H1247154
Kategori: Research program | Horse
Ansökningsår: 2012
Datum för slutrapport: 30 september 2018
Huvudsökande: Gunnar Klemetsdal
Organisation: Universitetet for miljø og biovitenskap (UMB)
E-postadress: Gunnar.Klemetsdal@umb.no
Telefon: ?
Medsökande: Nils Ivar Dolvik
Medsökande: Sigrid Lykkjen

The project aims to verify our current findings of QTLs with effect on osteochondrosis and Birkelandfracture in the Standarbred trotter. The project triples the sizes of the groups in the genome-wise association studies. The project will serve a basis for international involvement, either to identidy QTLs or in genomic selection.

Prosjektets mål er å verifiserer våre nåværende funn av QTLer med effect på osteochondrose og Birkelandfraktur hos varmblodstraver. Prosjektet tredobler størrelsen på forsøksgruppene i de genom-vide assosiasjonsstudiene. Prosjektet vil også være et springbrett for å komme inn i internasjonalt sammarbeid, enten for å finne QTLer, eller i genomisk seleksjon.

Ett mål i prosjektet var å verifisere QTL funnene som tidligere er rapportert av Lykkjen og medarbeidere på osteokondrose og Birkelandfraktur på varmblodstraver. Ved å øke materialet betydelig falt mange QTL bort, og bare en QTL på kromosom 28 var signifikant. En vil nå søke å tilnærme det mulige underliggende genet ved å utnytte kandidatgener. Med bare ett signifikant QTL funn, bør fremtidig forskning på OCD og POF ikke bare rettes inn mot å utnytte noe av genetisk varians ved å fokusere en QTL tilnærming, men heller ved å utnytte en mye større andel av genetisk variasjon gjennom genetisk seleksjon. Hos hest bør dette gjennomføres over populasjon av travere, men også inkludere data på varmblods ridehest. Relevante data vil i store trekk finnes i forskjellige forskningsprosjekt. Et slikt over-populasjons initiativ på OCD kan sees på som en modell for andre sykdommer, og andre arter, som heller ikke har etablert sykdomsregistering.

Osteochondrosis dissecans (OCD) and Birkelandfracture, are diseases mainly in the hock and fetlock joints of varmblooded horses, respectively, that increase the costs in the horse industry and affect animal welfare negatively, since many horses have to be operated. The diseases contribute to increased costs for treatment and restitution, reduced performance and income as well as reduced value of the animal itself. High frequencies of the diseases illustrate the importance of revealing the causative nature of OCD and POF.

Selection can be used as a preventive means towards such diseases, either on the quantitative trait loci (QTL) itself or on estimated breeding values, by summing the effect of all alleles into a genomic breeding value. The project aimed at verifying QTL findings that have been reported by Lykkjen and coworkers for OCD and POF in the Standardbred trotter. By considerably increasing the size of the material of Lykkjen and coworkers, only the finding of a QTL on chromosome 28 still held promise as a QTL. Our approach now is to use the candidate gene approach to possibly reveal the underlying causative gene. With only one QTL left to consider, this indicates that future research towards improving the genetics of OCD and POF should be approached by not only utilizing some of the genetic variance through a QTL approach, but rather to utilize more of the genetic variance through genomic selection, across populations of trotter, but also including data from riding horse populations. Such data will in main be available through research projects. Such an across-population initiative on OCD can be considered a model for other diseases, as well, and even for other species that do not either have a disease recording system in place.

In the same material, we also estimated the effect of inbreeding on racing performance. The effect was negative, i.e. that racing performance in Standardbred trotters is concluded depressed by inbreeding In corollary, crossbreeding is encouraged, and is one explanation of the recently increased contribution of French trotter in the Norwegian population of Standardbreds.

 

Antal träffar i projektbanken: 1676

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Projektnummer: H1347029 • Status: Avslutat • Datum för slutrapport: 19 januari 2018

Many horses in regular training/competing have an asymmetric motion pattern to a similar degree as horses examined for lameness. To what extent these asymmetries are caused by pain is unknown and might be a potential welfare problem for the horse. The aim is to investigate movement asymmetries in …

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Inter-row hoeing is an interesting alternative for weed control in organic and also in conventional agriculture for decreased use of herbicides. In an on-going project financed by SLF, “Climate robust cropping systems with inter-row hoeing against perennial and annual weeds in cereals” (SLF …

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The aim of the study is to investigate if treatment of calf pens with slaked lime will prevent spread of C. parvum and improve the calf health in herds with C. parvum associated diarrhea problems. Diarrhea is common in young dairy calves in Sweden and is often caused by C. parvum. The parasite is …

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Projektnummer: H1333180 • Status: Avslutat • Datum för slutrapport: 15 december 2017

Plant establishment is very critical for spring oilseed rape, especially under dry conditions on clay soils. With conventional tillage, the soil drying process in the spring gives little plant available water in the seedbed for small-grained seeds with shallow sowing depth. Alternatively, soil …

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Peter Mannberg,

Projektnummer: O-15-22-345 • Status: Avslutat • Datum för slutrapport: 14 december 2017

Energi & biomassa

The project goal is to demonstrate the technical feasibility for a production chain for composite applications based or reed canary grass. New business opportunities for agriculture will be evaluated and promoted. The project will use red canary grass as a constituent in biobased composite …

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Lena Holm, Sveriges Lantbruksuniversitet - SLU

Projektnummer: H1233176 • Status: Avslutat • Datum för slutrapport: 11 december 2017

Today's large and heavy equipment causes soil compaction, which can be minimized by concentrating all traffic to specific locations in the field. The concept is called Controlled Traffic Farming (CTF). Today there is also a strong trend to reduce the cultivation intensity. CTF reduces the need for …

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